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Rejuran: What It Does, When Results Appear, and Which Type to Choose
A skin booster designed to improve skin quality by supporting the skin’s natural repair process.
Intro
Rejuran is one of Korea’s best-known skin booster treatments.
Unlike fillers, which are designed to create immediate volume, Rejuran is focused on skin quality—helping improve texture, elasticity, hydration, and the overall condition of the skin over time.
This difference is important.
Patients sometimes expect to see a dramatic change immediately after treatment, but Rejuran works more gradually as the skin goes through its natural recovery and remodeling process.
So what exactly is Rejuran, when should you expect to notice a difference, and how do the different Rejuran formulations compare?
The key ingredient in Rejuran is PN, or Polynucleotide, derived from salmon DNA.
PN is injected into the skin to support tissue repair and improve the overall skin environment. Rejuran products are manufactured using PharmaResearch’s proprietary DNA-processing technology.
Rather than simply adding temporary moisture or volume, Rejuran is generally chosen to improve concerns such as:
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Fine skin texture
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Loss of elasticity
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Dry or tired-looking skin
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Fine lines
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Overall skin quality
The goal is not to change the shape of the face, but to help the skin look healthier and more resilient.
One of the most important things to understand about Rejuran is that results are gradual.
Immediately after treatment, small raised bumps may be visible at the injection sites. These typically settle within a few days, although recovery varies depending on skin thickness, injection method, and individual response.
Changes in skin texture and hydration may become noticeable over the following weeks.
Rather than judging the result immediately after one session, it is better to think of Rejuran as a treatment that develops progressively.
3. Why Does Rejuran Often Require More Than One Session?
Rejuran is not designed to create an instant filler-like effect.
Because the treatment works through a gradual skin-repair process, repeated sessions are often recommended to build and maintain the result.
A common initial treatment plan consists of approximately three sessions, with intervals adjusted according to the patient’s skin condition.
The manufacturer also notes that repeated treatments may enhance treatment response and duration.
At Rene Clinic, however, we do not apply the same schedule to every patient.
Skin thickness, age, dryness, elasticity, and previous treatments are considered before deciding the appropriate number and interval of sessions.
4. Rejuran vs. Rejuran HB Plus
Not all Rejuran products are the same.
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Rejuran
The original formulation is centered on PN and is commonly selected when the main goal is improving overall skin quality, elasticity, and texture.
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Rejuran HB Plus
PN + Hyaluronic Acid + Lidocaine, Hyaluronic acid adds a moisturizing component, while lidocaine is included to reduce discomfort during injection. The manufacturer reports lower treatment pain compared with the original formulation.
For patients who are particularly sensitive to injections or who also want additional hydration, Rejuran HB Plus may be a suitable option.
Rejuran is injected directly into the skin, so some discomfort is expected.
The relatively viscous nature of PN can make the injection feel more noticeable than some lighter skin boosters.
Pain level, however, varies considerably between patients.
Topical anesthesia and injection technique can help improve comfort, and Rejuran HB Plus may also be considered for patients who are particularly concerned about pain.
At Rene Clinic, the treatment method is selected not only according to the desired result, but also according to each patient’s comfort and skin condition.
6. What Should You Expect After Treatment?
Temporary reactions can include:
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Small raised injection bumps
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Mild redness
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Swelling
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Bruising or needle marks
The raised bumps usually improve naturally over the following few days.
After treatment, it is generally recommended to avoid excessive heat, strenuous exercise, sauna, and alcohol for several days and to keep the skin well moisturized.
Most importantly, do not press or massage the raised injection areas unless instructed by your doctor.
7. Who Is Rejuran Best Suited For?
Rejuran may be worth considering if your concerns are less about facial volume and more about the quality of the skin itself.
It may be suitable for patients concerned about:
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Fine lines
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Reduced elasticity
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Dry or rough skin
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Thin or tired-looking skin
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Early signs of skin aging
However, Rejuran cannot replace every aesthetic treatment.
Deep wrinkles, significant sagging, or facial volume loss may require lifting devices, fillers, collagen stimulators, or combination treatment.
The right treatment depends on what is actually causing the concern.
Closing
Rejuran is not a treatment designed to transform the face overnight.
Its strength lies in gradual improvement in skin quality, texture, elasticity, and overall condition.
That is also why the treatment should not be judged solely by the result of a single session.
At Rene Clinic, we first evaluate the patient’s skin condition and treatment goals before deciding the formulation, amount, injection method, and treatment interval.
Because when it comes to skin boosters, the most important question is not simply:
“Which product is popular?”
but rather:
“What does my skin actually need?”